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In the Veterans Affairs Nephropathy in Diabetes (VA NEPHRON-D) trial, isotretinoin joint damage no additional benefit over monotherapy was seen in patients receiving the combination of losartan and lisinopril compared to monotherapy; however, there was an increased incidence of hyperkalemia and acute renal injury?

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Some manufacturers state that absorption of oral doxycycline is not markedly influenced by simultaneous ingestion of food or milk and recommend taking doxycycline with food or milk if gastric irritation occurs upon administration.

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